Stanley L Hazen Selected Research

trimethylamine

1/2022	Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms.
1/2022	Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice.
12/2021	Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
1/2020	Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
1/2019	Dietary metabolism, the gut microbiome, and heart failure.
1/2019	l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
1/2019	Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
1/2016	Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
12/2015	Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.
1/2015	Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis.

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Stanley L Hazen Research Topics

Disease

64	Cardiovascular Diseases (Cardiovascular Disease) 10/2022 - 04/2003
60	Atherosclerosis 10/2022 - 10/2002
57	Inflammation (Inflammations) 01/2022 - 05/2002
46	Coronary Artery Disease (Coronary Atherosclerosis) 06/2022 - 04/2003
38	Myocardial Infarction 01/2022 - 03/2003
31	Heart Failure 01/2022 - 01/2005
29	Atherosclerotic Plaque (Atheroma) 01/2022 - 04/2003
29	Stroke (Strokes) 01/2022 - 07/2007
18	Acute Coronary Syndrome 01/2022 - 12/2003
14	Asthma (Bronchial Asthma) 10/2018 - 03/2003
13	Thrombosis (Thrombus) 01/2022 - 03/2016
12	Neoplasms (Cancer) 10/2021 - 06/2002
11	Obesity 01/2022 - 06/2006
10	Hypertension (High Blood Pressure) 01/2020 - 03/2005
8	Coronary Disease (Coronary Heart Disease) 01/2022 - 02/2007
8	Fibrosis (Cirrhosis) 12/2021 - 04/2010
8	Diabetes Mellitus 01/2020 - 07/2006
8	Systolic Heart Failure 02/2015 - 10/2008
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 07/2007
7	Non-alcoholic Fatty Liver Disease 01/2021 - 11/2008
6	Type 2 Diabetes Mellitus (MODY) 01/2021 - 02/2011
6	Heart Diseases (Heart Disease) 01/2021 - 04/2011
6	Insulin Resistance 01/2021 - 09/2009
6	Ventricular Remodeling 01/2020 - 03/2003
6	Infarction (Infarctions) 06/2017 - 03/2003
5	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 06/2005
5	Necrosis 01/2021 - 10/2003
5	Chest Pain (Chest Pains) 01/2019 - 10/2003
5	Left Ventricular Dysfunction 02/2015 - 09/2006
4	Dyslipidemias (Dyslipidemia) 01/2022 - 09/2007
4	Chronic Renal Insufficiency 12/2021 - 04/2013
4	Melanoma (Melanoma, Malignant) 05/2020 - 07/2013
3	Peripheral Arterial Disease 10/2021 - 10/2016

Drug/Important Bio-Agent (IBA)

70	trimethyloxamine (trimethylamine N-oxide)IBA 06/2022 - 04/2011
48	Peroxidase (Myeloperoxidase)IBA 01/2018 - 11/2002
38	Proteins (Proteins, Gene)FDA Link 05/2020 - 03/2003
31	Choline (Choline Chloride)IBA 01/2022 - 10/2006
31	Oxidants (Oxidizing Agents)IBA 01/2020 - 11/2002
23	Biomarkers (Surrogate Marker)IBA 12/2021 - 12/2007
20	CholesterolIBA 10/2022 - 01/2005
20	LipidsIBA 01/2022 - 03/2002
19	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 04/2003
17	omega-Chloroacetophenone (Mace)IBA 01/2022 - 09/2008
17	HDL LipoproteinsIBA 10/2020 - 01/2005
17	C-Reactive ProteinIBA 01/2020 - 10/2003
14	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2022 - 08/2004
14	trimethylamineIBA 01/2022 - 05/2013
14	EnzymesIBA 05/2020 - 08/2003
13	Carnitine (L-Carnitine)FDA LinkGeneric 01/2022 - 05/2013
12	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2020 - 01/2005
11	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 02/2008
11	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2020 - 10/2006
11	Arginine (L-Arginine)FDA Link 02/2013 - 07/2005
11	3-nitrotyrosineIBA 12/2007 - 05/2002
10	oxidized low density lipoproteinIBA 01/2018 - 10/2002
10	AntioxidantsIBA 01/2017 - 08/2003
9	Betaine (C.B.B.)FDA Link 01/2022 - 04/2011
9	Aryldialkylphosphatase (Paraoxonase)IBA 01/2018 - 03/2008
8	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 04/2003
7	arylesteraseIBA 01/2018 - 03/2008
7	Scavenger Receptors (Scavenger Receptor)IBA 09/2017 - 10/2002
7	Tyrosine (L-Tyrosine)FDA Link 04/2014 - 06/2004
6	CreatinineIBA 12/2021 - 03/2010
6	pro-brain natriuretic peptide (1-76)IBA 10/2021 - 04/2013
6	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 01/2019 - 01/2013
6	LDL CholesterolIBA 01/2018 - 04/2003
6	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2017 - 08/2003
6	HDL CholesterolIBA 09/2017 - 02/2007
6	Triglycerides (Triacylglycerol)IBA 01/2015 - 04/2007
6	Ceruloplasmin (Ferroxidase)IBA 12/2014 - 03/2010
6	CitrullineIBA 02/2013 - 07/2005
5	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2020 - 04/2013
5	CytokinesIBA 11/2018 - 10/2004
5	Lipoproteins (Lipoprotein)IBA 10/2013 - 02/2007
5	Fibrinogen (Factor I)FDA Link 07/2012 - 03/2004
5	Superoxide DismutaseIBA 05/2011 - 08/2003
5	Biological ProductsIBA 07/2010 - 03/2003
5	Reactive Nitrogen SpeciesIBA 06/2006 - 06/2002
4	LDL Lipoproteins (beta Lipoproteins)IBA 10/2022 - 10/2002
4	Anti-Bacterial Agents (Antibiotics)IBA 08/2021 - 02/2015
4	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 01/2017
4	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021 - 01/2016
4	Urea (Carbamide)FDA LinkGeneric 01/2019 - 10/2008
4	ArginaseIBA 01/2018 - 11/2004
4	Hemoglobins (Hemoglobin)IBA 04/2016 - 07/2005
4	Blood Proteins (Serum Proteins)IBA 09/2015 - 12/2003
4	Troponin IIBA 03/2015 - 05/2008
4	ApolipoproteinsIBA 02/2015 - 02/2007
4	Acute-Phase Proteins (Acute-Phase Protein)IBA 12/2014 - 03/2010
4	homocitrullineIBA 04/2013 - 10/2007
4	OrnithineIBA 03/2012 - 07/2005
4	Nitric Oxide Synthase (NO Synthase)IBA 03/2012 - 12/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009 - 10/2004
3	LyasesIBA 01/2022 - 10/2018
3	Atorvastatin (Lipitor)FDA Link 01/2022 - 07/2003
3	Lysine (L-Lysine)FDA Link 01/2022 - 11/2008
3	Apolipoproteins E (ApoE)IBA 12/2021 - 01/2016
3	Cystatin CIBA 12/2021 - 09/2012

Therapy/Procedure

24	Therapeutics 01/2022 - 04/2003
9	Transplantation 01/2022 - 10/2004